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4E-BP1–dependent translation in microglia controls mechanical hypersensitivity in male and female mice

Spinal microglia play a pivotal role in the development of neuropathic pain. Peripheral nerve injury induces changes in the transcriptional profile of microglia, including increased expression of components of the translational machinery. Whether microglial protein synthesis is stimulated following...

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Principais autores: Kevin C. Lister, Calvin Wong, Weihua Cai, Sonali Uttam, Patricia Stecum, Rose Rodrigues, Mehdi Hooshmandi, Nicole Brown, Jonathan Fan, Noe Francois-Saint-Cyr, Shannon Tansley, Volodya Hovhannisyan, Diana Tavares-Ferreira, Nikhil Nageshwar Inturi, Khadijah Mazhar, Alain Pacis, Jieyi Yang, Alfredo Ribeiro-da-Silva, Christos G. Gkogkas, Theodore J. Price, Jeffrey S. Mogil, Arkady Khoutorsky
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical Investigation 2025-06-01
Serier:The Journal of Clinical Investigation
Fag:
Cell biology
Neuroscience
Online adgang:https://doi.org/10.1172/JCI180190
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