Using recombinase‐mediated cassette exchange to engineer MIN6 insulin‐secreting cells based on a newly identified safe harbor locus

Abstract Aims/Introduction Recent studies have identified genomic and transcript level changes along with alterations in insulin secretion in patients with diabetes and in rodent models of diabetes. It is important to establish an efficient system for testing functional consequences of these changes...

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Detalhes bibliográficos

Principais autores:	Asami Furukawa, Aya Tanaka, Suguru Yamaguchi, Minami Kosuda, Midori Yamana, Akiko Nagasawa, Genta Kohno, Hisamitsu Ishihara
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Wiley 2021-12-01
coleção:	Journal of Diabetes Investigation
Assuntos:	Insulin secretion Recombination‐mediated cassette exchange Tetracycline‐regulated expression
Acesso em linha:	https://doi.org/10.1111/jdi.13646
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