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Bladder cancer therapy using a conformationally fluid tumoricidal peptide complex

Partially unfolded alpha-lactalbumin forms an oleic acid complex with antitumorigenic properties. Here, the authors define a structurally flexible, peptide-based oleate complex and report a phase I/II clinical trial where this complex is used to treat patients with bladder cancer.

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Auteurs principaux: Antonín Brisuda, James C. S. Ho, Pancham S. Kandiyal, Justin T-Y. Ng, Ines Ambite, Daniel S. C. Butler, Jaromir Háček, Murphy Lam Yim Wan, Thi Hien Tran, Aftab Nadeem, Tuan Hiep Tran, Anna Hastings, Petter Storm, Daniel L. Fortunati, Parisa Esmaeili, Hana Novotna, Jakub Horňák, Y. G. Mu, K. H. Mok, Marek Babjuk, Catharina Svanborg
Format: Artigo
Langue:Inglês
Publié: Nature Portfolio 2021-06-01
Collection:Nature Communications
Accès en ligne:https://doi.org/10.1038/s41467-021-23748-y
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