Escherichia coli BL21 adapts its central carbon metabolism to recombinant protein production and oxygen limitation

Abstract Background High-yielding recombinant protein expression systems often face challenges due to the metabolic burden caused by the competition for cellular resources, resulting in reduced growth and, hence, limiting their industrial applicability. Furthermore, industrial recombinant protein pr...

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Hlavní autoři:	Divyata Vilas Rane, Karen Lund Haaland, Åse Refsnes, Hege Skuggedal, Stinus Reklev Øverbø, Per Bruheim, Laura García-Calvo
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	BMC 2026-02-01
Edice:	Microbial Cell Factories
Témata:	Escherichia coli Recombinant protein production Microaerobic conditions Central carbon metabolome Metabolic burden
On-line přístup:	https://doi.org/10.1186/s12934-026-02924-z
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