Struggle To Survive: the Choir of Target Alteration, Hydrolyzing Enzyme, and Plasmid Expression as a Novel Aztreonam-Avibactam Resistance Mechanism

ABSTRACT Aztreonam-avibactam is a promising antimicrobial combination against multidrug-resistant organisms, such as carbapenemase-producing Enterobacterales. Resistance to aztreonam-avibactam has been found, but the resistance mechanism remains poorly studied. We recovered three Escherichia coli is...

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Detalles Bibliográficos

Principais autores:	Ke Ma, Yu Feng, Alan McNally, Zhiyong Zong
Formato:	Artigo
Idioma:	Inglês
Publicado:	American Society for Microbiology 2020-12-01
Series:	mSystems
Assuntos:	aztreonam-avibactam avibactam CMY penicillin-binding protein plasmid copy number Escherichia coli
Acceso en liña:	https://journals.asm.org/doi/10.1128/mSystems.00821-20
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