The reverse transcriptase encoded by LINE-1 retrotransposons in the genesis, progression and therapy of cancer

In higher eukaryotic genomes, Long Interspersed Nuclear Element 1 (LINE-1) retrotransposons represent a large family of repeated genomic elements. They transpose using a reverse transcriptase (RT), which they encode as part of the ORF2p product. RT inhibition in cancer cells, either via RNA interfer...

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Bibliographic Details

Main Authors:	Ilaria eSciamanna, Chiara eDe Luca, Corrado eSpadafora
Format:	Artigo
Language:	Inglês
Published:	Frontiers Media S.A. 2016-02-01
Series:	Frontiers in Chemistry
Subjects:	epigenetics reverse transcriptase tumorigenesis differentiation therapy cancer heterogeneity LINE-1 retrotransposons
Online Access:	http://journal.frontiersin.org/Journal/10.3389/fchem.2016.00006/full
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