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CCR1 inhibition sensitizes multiple myeloma cells to glucocorticoid therapy

Glucocorticoids (GC) are cornerstone drugs in the treatment of multiple myeloma (MM). Because MM cells exploit the bone marrow microenvironment to obtain growth and survival signals, resistance to glucocorticoid-induced apoptosis emerges, yet the underlying mechanisms remain poorly characterized. He...

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Autori principali: Bert Luyckx, Maaike Van Trimpont, Fien Declerck, Eleni Staessens, Annick Verhee, Sara T’Sas, Sven Eyckerman, Fritz Offner, Pieter Van Vlierberghe, Steven Goossens, Dorien Clarisse, Karolien De Bosscher
Natura: Artigo
Lingua:Inglês
Pubblicazione: Elsevier 2025-05-01
Serie:Pharmacological Research
Soggetti:
Multiple myeloma
Glucocorticoids
Glucocorticoid resistance
Chemokine receptor
Accesso online:http://www.sciencedirect.com/science/article/pii/S1043661825001343
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