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Interplay of Mendelian and polygenic risk factors in Arab breast cancer patients

Abstract Background Breast cancer patients from the indigenous Arab population present much earlier than patients from Western countries and have traditionally been underrepresented in cancer genomics studies. The contribution of polygenic and Mendelian risk toward the earlier onset of breast cancer...

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Principais autores: Mohammed Al-Jumaan, Hoyin Chu, Abdullah Alsulaiman, Sabrina Y. Camp, Seunghun Han, Riaz Gillani, Yousef Al Marzooq, Fatmah Almulhim, Chittibabu Vatte, Areej Al Nemer, Afnan Almuhanna, Eliezer M. Van Allen, Amein Al-Ali, Saud H. AlDubayan
Format: Artigo
Sprog:Inglês
Udgivet: BMC 2023-09-01
Serier:Genome Medicine
Fag:
Low-pass whole genome sequencing
Imputation
Polygenic risk score
Breast cancer
Arab population
Age of onset
Online adgang:https://doi.org/10.1186/s13073-023-01220-4
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