Increased functional potency of multi-edited CAR-T cells manufactured by a non-viral transfection system

Chimeric antigen receptor (CAR)-T cell therapy represents a breakthrough for the treatment of hematological malignancies. However, to treat solid tumors and certain hematologic cancers, next-generation CAR-T cells require further genetic modifications to overcome some of the current limitations. Imp...

Ausführliche Beschreibung

Bibliografische Detailangaben

Hauptverfasser:	Aine O’Sullivan, Sarah Case, Aisling McCrudden, Emer Hackett, Louise Gallagher, Darren Martin, Gillian P. Johnson, Kirti Mahadik, Thomas Kienzle, Jude Kevin Lim, Aya Nashat, Kartik Srinivasan, Mark W. Lowdell, Lisa O’Flynn, Jamie Frankish
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Elsevier 2025-03-01
Schriftenreihe:	Molecular Therapy: Methods & Clinical Development
Schlagworte:	CAR-T genetic engineering adoptive cell therapy metabolism cell avidity cell cytotoxicity
Online-Zugang:	http://www.sciencedirect.com/science/article/pii/S2329050124002055
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