Application of PVP VA 64 and Poloxamer 188/407 in Solid Dispersion Technology for Improving Solubility of Valsartan

Valsartan, Biopharmaceutical Classification System (BCS) class II drug, exhibits pH-dependent solubility in the gastrointestinal tract, which increases at pH levels above 5. Its low solubility results in a bioavailability of only 23%, necessitating efforts to enhance it. This study aims to improve t...

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Detalhes bibliográficos

Principais autores:	Sulastari Cahyani, Teuku Nanda Saifullah Sulaiman, Marlyn Dian Laksitorini
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Universitas Indonesia 2024-08-01
coleção:	Pharmaceutical Sciences and Research
Assuntos:	valsartan solid dispersion saturated solubility dissolution rate
Acesso em linha:	https://scholarhub.ui.ac.id/psr/vol11/iss2/4/
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