The Sec61 translocon limits IRE1α signaling during the unfolded protein response
IRE1α is an endoplasmic reticulum (ER) localized endonuclease activated by misfolded proteins in the ER. Previously, we demonstrated that IRE1α forms a complex with the Sec61 translocon, to which its substrate XBP1u mRNA is recruited for cleavage during ER stress (Plumb et al., 2015). Here, we probe...
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| Hoofdauteurs: | , , , |
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| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
eLife Sciences Publications Ltd
2017-05-01
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| Reeks: | eLife |
| Onderwerpen: | |
| Online toegang: | https://elifesciences.org/articles/27187 |
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