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Tivozanib mediated inhibition of c-Kit/SCF signaling on Tregs and MDSCs and reversal of tumor induced immune suppression correlates with survival of HCC patients

The immune modulatory effect of tivozanib, a tyrosine kinase inhibitor, and the underlying immune mechanisms impacting survival of HCC patients have not been investigated. Pre-clinical studies have shown that tivozanib reduces Tregs and MDSCs accumulation through inhibition of c-Kit/SCF axis. We rat...

Ausführliche Beschreibung

Gespeichert in:
Hauptverfasser: Suresh Gopi Kalathil, Katy Wang, Alan Hutson, Renuka Iyer, Yasmin Thanavala
Format: Artigo
Sprache:Inglês
Veröffentlicht: Taylor & Francis Group 2020-01-01
Schriftenreihe:OncoImmunology
Schlagworte:
tivozanib
hcc
tregs
mdsc
c-kit/scf
survival
Online-Zugang:http://dx.doi.org/10.1080/2162402X.2020.1824863
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