Andrographolide suppresses chondrosarcoma cell migration and invasion by inhibiting the PI3K/Akt/mTOR signaling pathway and activating autophagy

ObjectiveChondrosarcoma, a malignant bone tumor, exhibits a high incidence rate. This study employed network pharmacology and cell-based experiments to explore the molecular mechanisms by which andrographolide (Andro) suppressed the migration and invasion of chondrosarcoma cells.MethodsAndro’s targe...

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Main Authors: Chun-Fei Wu, Li-xin Ouyang, Wan-hao Zhang, Shuo Yang, Xian-Xing Zhong, Yong Lin, Shuai Fan, Peng Li, Zu-Jian Liang
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2025-09-01
Serier:Frontiers in Oncology
Fag:
andrographolide
chondrosarcoma
PI3K/AKT/mTOR
network pharmacology
in vitro experiments
Online adgang:https://www.frontiersin.org/articles/10.3389/fonc.2025.1622666/full
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