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Ratios of Acetaminophen Metabolites Identify New Loci of Pharmacogenetic Relevance in a Genome-Wide Association Study

Genome-wide association studies (GWAS) with non-targeted metabolomics have identified many genetic loci of biomedical interest. However, metabolites with a high degree of missingness, such as drug metabolites and xenobiotics, are often excluded from such studies due to a lack of statistical power an...

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Principais autores: Gaurav Thareja, Anne M. Evans, Spencer D. Wood, Nisha Stephan, Shaza Zaghlool, Anna Halama, Gabi Kastenmüller, Aziz Belkadi, Omar M. E. Albagha, The Qatar Genome Program Research Consortium, Karsten Suhre
Format: Artigo
Sprog:Inglês
Udgivet: MDPI AG 2022-05-01
Serier:Metabolites
Fag:
medication
drug metabolites
population studies
non-targeted metabolomics
genome-wide association studies
acetaminophen metabolism
Online adgang:https://www.mdpi.com/2218-1989/12/6/496
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