Fluorinated and Non-Fluorinated 1,4-Diarylpyrazoles via MnO₂-Mediated Mechanochemical Deacylative Oxidation of 5-Acylpyrazolines

A solvent-free two-step synthesis of polyfunctionalized pyrazoles under ball-milling mechanochemical conditions was developed. The protocol comprises (3 + 2)-cycloaddition of in situ generated nitrile imines and chalcones, followed by oxidation of the initially formed 5-acylpyrazolines with activate...

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Autors principals:	Greta Utecht-Jarzyńska, Anna Kowalczyk, Marcin Jasiński
Format:	Artigo
Idioma:	Inglês
Publicat:	MDPI AG 2022-12-01
Col·lecció:	Molecules
Matèries:	pyrazole nitrile imine mechanochemistry (3 + 2)-cycloaddition deacylation oxidation
Accés en línia:	https://www.mdpi.com/1420-3049/27/23/8446
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