Human Obesity Induces Dysfunction and Early Senescence in Adipose Tissue-Derived Mesenchymal Stromal/Stem Cells

BackgroundChronic inflammatory conditions like obesity may adversely impact the biological functions underlying the regenerative potential of mesenchymal stromal/stem cells (MSC). Obesity can impair MSC function by inducing cellular senescence, a growth-arrest program that transitions cells to a pro...

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Autors principals:	Sabena M. Conley, LaTonya J. Hickson, Todd A. Kellogg, Travis McKenzie, Julie K. Heimbach, Timucin Taner, Hui Tang, Kyra L. Jordan, Ishran M. Saadiq, John R. Woollard, Busra Isik, Mohsen Afarideh, Tamar Tchkonia, James L. Kirkland, Lilach O. Lerman
Format:	Artigo
Idioma:	Inglês
Publicat:	Frontiers Media S.A. 2020-03-01
Col·lecció:	Frontiers in Cell and Developmental Biology
Matèries:	obesity mesenchymal stem cells cellular senescence adipose tissue cellular dysfunction
Accés en línia:	https://www.frontiersin.org/article/10.3389/fcell.2020.00197/full
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