Increased bone marrow interleukin-7 (IL-7)/IL-7R levels but reduced IL-7 responsiveness in HIV-positive patients lacking CD4+ gain on antiviral therapy.

BACKGROUND: The bone marrow (BM) cytokine milieu might substantially affect T-lymphocyte homeostasis in HIV-positive individuals. Interleukin-7 (IL-7) is a bone marrow-derived cytokine regulating T-cell homeostasis through a CD4+-driven feedback loop. CD4+ T-lymphopenia is associated with increased...

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Detalhes bibliográficos

Principais autores:	Giusi Maria Bellistrì, Anna Casabianca, Esther Merlini, Chiara Orlandi, Giulio Ferrario, Luca Meroni, Massimo Galli, Mauro Magnani, Antonella d'Arminio Monforte, Giulia Marchetti
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Public Library of Science (PLoS) 2010-01-01
coleção:	PLoS ONE
Acesso em linha:	http://europepmc.org/articles/PMC3013120?pdf=render
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