A covalent chemical probe for Chikungunya nsP2 cysteine protease with antialphaviral activity and proteome-wide selectivity

Abstract Chikungunya is a mosquito-borne viral disease that causes fever and severe joint pain for which there is no direct acting drug treatments. Vinyl sulfone SGC-NSP2PRO-1 (3) was identified as a potent inhibitor of the nsP2 cysteine protease (nsP2pro) that reduced viral titer against infectious...

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Egile Nagusiak:	Anirban Ghoshal, Edwin G. Tse, Mohammad Anwar Hossain, Kesatebrhan Haile Asressu, Eric M. Merten, John D. Sears, Stefanie Howell, Sumera Perveen, Jane Burdick, Noah L. Morales, Sabian A. Martinez, Isabella Law, Bennett J. Davenport, Thomas E. Morrison, Zachary J. Streblow, Daniel N. Streblow, Angie L. Mordant, Thomas S. Webb, Aurora Cabrera, Laura E. Herring, Cheryl H. Arrowsmith, Kenneth H. Pearce, Nathaniel J. Moorman, Mark T. Heise, Rafael M. Couñago, Peter J. Brown, Timothy M. Willson
Formatua:	Artigo
Hizkuntza:	Inglês
Argitaratua:	Nature Portfolio 2025-03-01
Saila:	Scientific Reports
Gaiak:	Covalent inhibitor Cysteine protease Chemical probe Antiviral Alphavirus
Sarrera elektronikoa:	https://doi.org/10.1038/s41598-025-91673-x
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