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A new candidate vaccine for human brucellosis based on influenza viral vectors: a preliminary investigation for the development of an immunization schedule in a guinea pig model

Abstract Background A new candidate vector vaccine against human brucellosis based on recombinant influenza viral vectors (rIVV) subtypes H5N1 expressing Brucella outer membrane protein (Omp) 16, L7/L12, Omp19 or Cu–Zn SOD proteins has been developed. This paper presents the results of the study of...

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Principais autores: Dina Bugybayeva, Zhailaubay Kydyrbayev, Nadezhda Zinina, Nurika Assanzhanova, Bolat Yespembetov, Yerken Kozhamkulov, Kunsulu Zakarya, Sholpan Ryskeldinova, Kaissar Tabynov
Formato: Artigo
Idioma:Inglês
Publicado em: BMC 2021-02-01
coleção:Infectious Diseases of Poverty
Assuntos:
Human brucellosis
Influenza viral vectors
Vaccine candidate
Protection
Guinea pigs
Immunization route
Acesso em linha:https://doi.org/10.1186/s40249-021-00801-y
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