A positive feedback loop between Myc and aerobic glycolysis sustains tumor growth in a Drosophila tumor model

Cancer cells usually exhibit aberrant cell signaling and metabolic reprogramming. However, mechanisms of crosstalk between these processes remain elusive. Here, we show that in an in vivo tumor model expressing oncogenic Drosophila Homeodomain-interacting protein kinase (Hipk), tumor cells display e...

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Hlavní autoři:	Kenneth Kin Lam Wong, Jenny Zhe Liao, Esther M Verheyen
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	eLife Sciences Publications Ltd 2019-07-01
Edice:	eLife
Témata:	Drosophila cancer model phosphofructokinase aerobic glycolysis MYC phosphofructokinase 2 Hipk
On-line přístup:	https://elifesciences.org/articles/46315
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