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Abrogation of the RNase activity of Erns in a low virulence classical swine fever virus enhances the humoral immune response and reduces virulence, transmissibility, and persistence in pigs

The prevalence of low virulence classical swine fever virus (CSFV) strains makes viral eradication difficult in endemic countries. However, the determinants for natural CSFV attenuation and persistence in the field remain unidentified. The aim of the present study was to assess the role of the RNase...

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Principais autores: Miaomiao Wang, José Alejandro Bohórquez, Yoandry Hinojosa, Sara Muñoz-González, Markus Gerber, Liani Coronado, Carmen Laura Perera, Matthias Liniger, Nicolas Ruggli, Llilianne Ganges
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis Group 2021-12-01
coleção:Virulence
Assuntos:
classical swine fever virus (csfv)
erns rnase activity
viral replication
type i ifn
viral attenuation
viral persistence
viral transmission
humoral response
pestivirus
Acesso em linha:http://dx.doi.org/10.1080/21505594.2021.1959715
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