The bacterial RNA polymerase-associated CarD protein couples promoter activity to DNA supercoiling
Abstract RNA polymerase (RNAP) must unwind duplex DNA prior to transcription initiation. In bacteria, unwinding starts at a DNA motif called the promoter −10 element. Specifically, non-template strand bases interact with RNAP to trigger the process. A protein called CarD can support −10 element open...
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| Asıl Yazarlar: | , , |
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| Materyal Türü: | Artigo |
| Dil: | Inglês |
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Nature Portfolio
2026-02-01
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| Seri Bilgileri: | Nature Communications |
| Online Erişim: | https://doi.org/10.1038/s41467-026-69038-3 |
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