CBX2 promotes cisplatin resistance in ovarian cancer via SIAH2-mediated β-catenin stabilization and ATG9B-dependent autophagy activation

Abstract Background Platinum-based chemotherapy is the first-line therapeutic strategy for ovarian cancer (OC), and resistance to it adversely affects most OC patients. CBX2 plays an essential role in cancer progression and is widely thought to be involved in cisplatin (DDP) resistance. This study a...

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Detalhes bibliográficos

Principais autores:	Xinxin Kou, Lijie Dong, Zheng Zhao, Xiaoxia Yang, Yuanjing Hu
Formato:	Artigo
Idioma:	Inglês
Publicado em:	BMC 2026-01-01
coleção:	Journal of Ovarian Research
Assuntos:	Ovarian cancer Cisplatin resistance Autophagy CBX2 Wnt/β-catenin pathway
Acesso em linha:	https://doi.org/10.1186/s13048-025-01944-4
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