PAF1c links S-phase progression to immune evasion and MYC function in pancreatic carcinoma
Abstract In pancreatic ductal adenocarcinoma (PDAC), endogenous MYC is required for S-phase progression and escape from immune surveillance. Here we show that MYC in PDAC cells is needed for the recruitment of the PAF1c transcription elongation complex to RNA polymerase and that depletion of CTR9, a...
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| Principais autores: | , , , , , , , , , , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Portfolio
2024-02-01
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| coleção: | Nature Communications |
| Acesso em linha: | https://doi.org/10.1038/s41467-024-45760-8 |
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