(2<i>R</i>, 4<i>S</i>, 5<i>S</i>) 1-(4-(4-(((7-Chloroquinolin-4-yl)amino)methyl)-1<i>H</i>-1,2,3-triazol-1-yl)-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1<i>H</i>,3<i>H</i>)-dione

1,2,3-triazole pharmacophore is a widely recognized motif used for a variety of applications, including drug discovery, chemical biology, and materials science. We herein report the synthesis of a derivative of azidothymidine (AZT), which was combined with the 7-chloro quinoline scaffold through a 1...

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Principais autores:	Houin Kuan, Yuhan Xie, Yuzhu Guo, Alessandra Gianoncelli, Giovanni Ribaudo, Paolo Coghi
Formato:	Artigo
Idioma:	Inglês
Publicado em:	MDPI AG 2023-07-01
Colecção:	Molbank
Assuntos:	HIV 1,2,3-triazole drug discovery molecular docking
Acesso em linha:	https://www.mdpi.com/1422-8599/2023/3/M1681
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