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Genome-wide detection of loss of heterozygosity and copy number variation in a human lung large cell carcinoma cell line by affymetrix single-nucleotide polymorphism array 500K

Background and objective Loss of heterozygosity (LOH) and Copy number copy number variation (CNV) of DNA sequences is a common feature of cancer genomes, which is thought to be linked to tumorigenesis and progression. High-density single-nucleotide polymorphism (SNP) genotyping array are able to pro...

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Principais autores: Bin HU, Jun CHEN, Hongyu LIU, Heng WU, Zhihao WU, Yuli WANG, Yun BAI, Ying LI, Qinghua ZHOU
Formato: Artigo
Idioma:Chinês
Publicado: Chinese Anti-Cancer Association; Chinese Antituberculosis Association 2008-06-01
Series:Chinese Journal of Lung Cancer
Assuntos:
Lung neoplasms
Single-nucleotide polymorphism
Loss of heterozygosity
Gene copy number
Microarray
Acceso en liña:http://www.lungca.org/index.php?journal=01&page=article&op=view&path[]=10.3779%2Fj.issn.1009-3419.2008.03.017&path[]=76
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