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Molecular Profiling of Mouse Models of Loss or Gain of Function of the KCNT1 (Slack) Potassium Channel and Antisense Oligonucleotide Treatment

The potassium sodium-activated channel subtype T member 1 (<i>KCNT1</i>) gene encodes the Slack channel K<sub>Na</sub>1.1, which is expressed in neurons throughout the brain. Gain-of-function variants in <i>KCNT1</i> are associated with a spectrum of epilepsy syndromes, and mice carrying those varia...

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Principais autores: Fangxu Sun, Huafeng Wang, Jing Wu, Imran H. Quraishi, Yalan Zhang, Maysam Pedram, Benbo Gao, Elizabeth A. Jonas, Viet Nguyen, Sijia Wu, Omar S. Mabrouk, Paymaan Jafar-nejad, Leonard K. Kaczmarek
Formato: Artigo
Idioma:Inglês
Publicado: MDPI AG 2024-11-01
Series:Biomolecules
Assuntos:
slack
KCNT1
K<sub>Na</sub>1.1
epilepsy
intellectual disability
EIMFS
Acceso en liña:https://www.mdpi.com/2218-273X/14/11/1397
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