SERPINA1 PiZ and PiS heterozygotes and lung function decline in the SAPALDIA cohort.

<h4>Background</h4>Severe alpha1-antitrypsin (AAT) deficiency is a strong risk factor for COPD. But the impact of gene variants resulting in mild or intermediate AAT deficiency on the longitudinal course of respiratory health remains controversial. There is indication from experimental studies that...

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Hauptverfasser:	Gian-Andri Thun, Ilaria Ferrarotti, Medea Imboden, Thierry Rochat, Margaret Gerbase, Florian Kronenberg, Pierre-Olivier Bridevaux, Elisabeth Zemp, Michele Zorzetto, Stefania Ottaviani, Erich W Russi, Maurizio Luisetti, Nicole M Probst-Hensch
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Public Library of Science (PLoS) 2012-01-01
Schriftenreihe:	PLoS ONE
Online-Zugang:	https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22912729/pdf/?tool=EBI
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SERPINA1 PiZ and PiS heterozygotes and lung function decline in the SAPALDIA cohort.

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