Contrasting functions of CD73 and adenosine in CD8+ T-cell exhaustion during antitumor immunity

T-cell exhaustion is a state of functional decline in T cells, driven by chronic antigen exposure and inhibitory signals within the tumor microenvironment. Exhausted CD8+ T cells (Tex) derive from precursor exhausted T cells (Tpex), a self-renewing population responsible for the proliferative burst...

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Principais autores:	Juan Saavedra-Almarza, Solange Gouët, Felipe Malgue, Catalina Bascuñan, Andrés Hernández-Oliveras, Joaquín De la Rosa, Javiera Reyes-Alvarez, Camilo Villaman, José Corrales-Bermúdez, Justine Castañeda, Moira García-Gómez, Alberto J.M. Martin, Álvaro Lladser, Mario Rosemblatt, María Rosa Bono, Daniela Sauma
Format:	Artigo
Jezik:	Inglês
Izdano:	Taylor & Francis Group 2026-12-01
Serija:	OncoImmunology
Teme:	Exhausted CD8+ T cells Ecto-5′; NT CD73 Adenosine A2AR signaling melanoma
Online dostop:	https://www.tandfonline.com/doi/10.1080/2162402X.2026.2642458
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