The IL1β-IL1R signaling is involved in the stimulatory effects triggered by hypoxia in breast cancer cells and cancer-associated fibroblasts (CAFs)

Abstract Background Hypoxia plays a relevant role in tumor-related inflammation toward the metastatic spread and cancer aggressiveness. The pro-inflammatory cytokine interleukin-1β (IL-β) and its cognate receptor IL1R1 contribute to the initiation and progression of breast cancer determining pro-tum...

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Главные авторы:	Rosamaria Lappano, Marianna Talia, Francesca Cirillo, Damiano Cosimo Rigiracciolo, Domenica Scordamaglia, Rita Guzzi, Anna Maria Miglietta, Ernestina Marianna De Francesco, Antonino Belfiore, Andrew H. Sims, Marcello Maggiolini
Формат:	Artigo
Язык:	Inglês
Опубликовано:	BMC 2020-08-01
Серии:	Journal of Experimental & Clinical Cancer Research
Предметы:	Hypoxia Hypoxia inducible factor-1α (HIF-1α) Interleukin-1β (IL-β) G protein estrogen receptor (GPER) Breast cancer Cancer-associated fibroblasts (CAFs)
Online-ссылка:	http://link.springer.com/article/10.1186/s13046-020-01667-y
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