Hypomethylation-enhanced CRTC2 expression drives malignant phenotypes and primary resistance to immunotherapy in hepatocellular carcinoma

Summary: The cyclic AMP-responsive element-binding protein (CREB)-regulated transcription coactivator 2 (CRTC2) is a crucial regulator of hepatic lipid metabolism and gluconeogenesis and correlates with tumorigenesis. However, the mechanism through which CRTC2 regulates hepatocellular carcinoma (HCC...

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Detalhes bibliográficos

Principais autores:	Ruizhi Zhang, Jingjing Dai, Feifan Yao, Suiqing Zhou, Wei Huang, Jiali Xu, Kai Yu, Yining Chen, Boqiang Fan, Liren Zhang, Jing Xu, Qing Li
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Elsevier 2024-06-01
Colecção:	iScience
Assuntos:	Molecular biology Immunology Cancer
Acesso em linha:	http://www.sciencedirect.com/science/article/pii/S2589004224010435
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