DNA nanostructures prevent the formation of and convert toxic amyloid proteospecies into cytocompatible and biodegradable spherical complexes

Abstract The deposition of insoluble proteinaceous aggregates in the form of amyloid fibrils within the extracellular space of tissues is associated with numerous diseases. The development of molecular approaches to arrest amyloid formation and prevent cellular degeneration remains very challenging...

Ausführliche Beschreibung

Bibliografische Detailangaben

Hauptverfasser:	Nadjib Kihal, Phuong Trang Nguyen, Ali Nazemi, Andrea A. Greschner, Marc A. Gauthier, Steve Bourgault
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Wiley 2024-06-01
Schriftenreihe:	Aggregate
Schlagworte:	amyloid cytotoxicity DNA nanostructures islet amyloid polypeptide oligomers self‐assembly
Online-Zugang:	https://doi.org/10.1002/agt2.502
Tags:	Tag hinzufügen Keine Tags, Fügen Sie das erste Tag hinzu!