Functional Characterization of Alternative and Classical Pathway C3/C5 Convertase Activity and Inhibition Using Purified Models

Complement is essential for the protection against infections; however, dysregulation of complement activation can cause onset and progression of numerous inflammatory diseases. Convertase enzymes play a central role in complement activation and produce the key mediators of complement: C3 convertase...

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Hlavní autoři:	Seline A. Zwarthoff, Evelien T. M. Berends, Sanne Mol, Maartje Ruyken, Piet C. Aerts, Mihály Józsi, Carla J. C. de Haas, Suzan H. M. Rooijakkers, Ronald D. Gorham
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Frontiers Media S.A. 2018-07-01
Edice:	Frontiers in Immunology
Témata:	innate immunity inflammatory disease convertase enzymes complement complement therapeutics multi-molecular proteases
On-line přístup:	https://www.frontiersin.org/article/10.3389/fimmu.2018.01691/full
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