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MICMIC: identification of DNA methylation of distal regulatory regions with causal effects on tumorigenesis

Abstract Aberrant promoter methylation is a common mechanism for tumor suppressor inactivation in cancer. We develop a set of tools to identify genome-wide DNA methylation in distal regions with causal effect on tumorigenesis called MICMIC. Many predictions are directly validated by dCas9-based epig...

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Principais autores: Yin Tong, Jianlong Sun, Chi Fat Wong, Qingzheng Kang, Beibei Ru, Ching Ngar Wong, April Sheila Chan, Suet Yi Leung, Jiangwen Zhang
Formato: Artigo
Idioma:Inglês
Publicado em: BMC 2018-06-01
coleção:Genome Biology
Assuntos:
DNA methylation
Enhancer
Bioinformatics
Cancer
Information theoretic approaches
Epigenetic editing
Acesso em linha:http://link.springer.com/article/10.1186/s13059-018-1442-0
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