Manzamine A reduces androgen receptor transcription and synthesis by blocking E2F8‐DNA interactions and effectively inhibits prostate tumor growth in mice

The androgen receptor (AR) is the main driver in the development of castration‐resistant prostate cancer, where the emergence of AR splice variants leads to treatment‐resistant disease. Through detailed molecular studies of the marine alkaloid manzamine A (MA), we identified transcription factor E2F...

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Bibliografische gegevens

Hoofdauteurs:	Dev Karan, Seema Dubey, Sumedha Gunewardena, Kenneth A. Iczkowski, Manohar Singh, Pengyuan Liu, Angelo Poletti, Yeun‐Mun Choo, Hui‐Zi Chen, Mark T. Hamann
Formaat:	Artigo
Taal:	Inglês
Gepubliceerd in:	Wiley 2024-08-01
Reeks:	Molecular Oncology
Onderwerpen:	androgen receptor E2F8 manzamine A prostate cancer
Online toegang:	https://doi.org/10.1002/1878-0261.13637
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