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Mechanotransduction Impairment in Primary Fibroblast Model of Krabbe Disease

Krabbe disease (KD) is a genetic disorder caused by the absence of the galactosylceramidase (GALC) functional enzyme. No cure is currently available. Here, we investigate the mechanotransduction process in primary fibroblasts collected from the twitcher mouse, a natural KD murine model. Thanks to me...

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Furkejuvvon:
Váldodahkkit: Roberta Mezzena, Ambra Del Grosso, Roberto Maria Pellegrino, Husam B. R. Alabed, Carla Emiliani, Ilaria Tonazzini, Marco Cecchini
Materiálatiipa: Artigo
Giella:Inglês
Almmustuhtton: MDPI AG 2023-03-01
Ráidu:Biomedicines
Fáttát:
mechanotransduction
Krabbe disease
focal adhesions
migration
autophagy
Liŋkkat:https://www.mdpi.com/2227-9059/11/3/927
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