Vulnerable Parkin Loss-of-Function Drosophila Dopaminergic Neurons Have Advanced Mitochondrial Aging, Mitochondrial Network Loss and Transiently Reduced Autophagosome Recruitment

Selective degeneration of substantia nigra dopaminergic (DA) neurons is a hallmark pathology of familial Parkinson’s disease (PD). While the mechanism of degeneration is elusive, abnormalities in mitochondrial function and turnover are strongly implicated. An Autosomal Recessive-Juvenile Parkinsonis...

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主要な著者:	Juliana Cackovic, Susana Gutierrez-Luke, Gerald B. Call, Amber Juba, Stephanie O’Brien, Charles H. Jun, Lori M. Buhlman
フォーマット:	Artigo
言語:	Inglês
出版事項:	Frontiers Media S.A. 2018-02-01
シリーズ:	Frontiers in Cellular Neuroscience
主題:	parkin neurodegeneration dopaminergic neurons Parkinson’s disease autophagy mitochondria
オンライン･アクセス:	http://journal.frontiersin.org/article/10.3389/fncel.2018.00039/full
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