Simultaneous Semi-Mechanistic Population Pharmacokinetic Modeling Analysis of Enalapril and Enalaprilat Serum and Urine Concentrations From Child Appropriate Orodispersible Minitablets

Enalapril is recommended as the first line of therapy and is proven to improve survival rates for treatment of Pediatric Heart Failure; however, an approved drug and child appropriate dosage formulation is still absent. The present analysis was conducted to perform a detailed model informed populati...

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Príomhchruthaitheoirí:	Muhammad Faisal, Willi Cawello, Bjoern B. Burckhardt, Jan de Hoon, Stephanie Laer, LENA Consortium
Formáid:	Artigo
Teanga:	Inglês
Foilsithe / Cruthaithe:	Frontiers Media S.A. 2019-07-01
Sraith:	Frontiers in Pediatrics
Ábhair:	enalapril enalaprilat heart failure population pharmacokinetics modeling analysis NONMEM orodispersible mini-tablets
Rochtain ar líne:	https://www.frontiersin.org/article/10.3389/fped.2019.00281/full
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