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The Spike Protein of SARS-CoV-2 Impairs Lipid Metabolism and Increases Susceptibility to Lipotoxicity: Implication for a Role of Nrf2

Coronavirus disease 2019 (COVID-19) patients show lipid metabolic alterations, but the mechanism remains unknown. In this study, we aimed to investigate whether the Spike protein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) impairs lipid metabolism in host cells. We generated a Sp...

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Principais autores: Vi Nguyen, Yuping Zhang, Chao Gao, Xiaoling Cao, Yan Tian, Wayne Carver, Hippokratis Kiaris, Taixing Cui, Wenbin Tan
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI AG 2022-06-01
coleção:Cells
Assuntos:
spike protein
SARS-CoV-2
lipid metabolism
lipotoxicity
autophagy
ferroptosis
Acesso em linha:https://www.mdpi.com/2073-4409/11/12/1916
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