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Evaluation of the impact of antibody fragments on aggregation of intact molecules via size exclusion chromatography coupled with native mass spectrometry

Aggregates are recognized as one of the most critical product-related impurities in monoclonal antibody (mAb)-based therapeutics due to their negative impact on the stability and safety of the drugs. So far, investigational efforts have primarily focused on understanding the causes and effects of mA...

Ausführliche Beschreibung

Gespeichert in:
Hauptverfasser: Jing Xu, John E. Coughlin, Malgorzata Szyjka, Serene Jabary, Sonal Saluja, Zoran Sosic, Yunqiu Chen, Chong-Feng Xu
Format: Artigo
Sprache:Inglês
Veröffentlicht: Taylor & Francis Group 2024-12-01
Schriftenreihe:mAbs
Schlagworte:
Aggregation
aggregation rate
fragments
heterodimers
monoclonal antibody
native mass spectrometry
Online-Zugang:https://www.tandfonline.com/doi/10.1080/19420862.2024.2334783
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