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Dual short upstream open reading frames control translation of a herpesviral polycistronic mRNA.

The Kaposi's sarcoma-associated herpesvirus (KSHV) protein kinase, encoded by ORF36, functions to phosphorylate cellular and viral targets important in the KSHV lifecycle and to activate the anti-viral prodrug ganciclovir. Unlike the vast majority of mapped KSHV genes, no viral transcript has been i...

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Principais autores: Lisa M Kronstad, Kevin F Brulois, Jae U Jung, Britt A Glaunsinger
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science (PLoS) 2013-01-01
Series:PLoS Pathogens
Acceso en liña:http://europepmc.org/articles/PMC3561293?pdf=render
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