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Efficacy of local convection enhanced delivery of chemotherapy using an intracerebral osmotic pump in a rat model of glioblastoma

BackgroundModern protocols for the treatment of glioblastoma multiforme (GBM) involve resection surgery, followed by chemotherapy and radiation therapy and subsequently adjuvant chemotherapy. While modestly successful in prolonging overall survival, peripherally administered chemotherapy drugs have...

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Автори: John McDaid, Julian E. Bailes, Neilank K. Jha, George Bobustuc, Reed Berlet, Cassidy Kessinger, Eliana Whitcomb, John M. Lee, Daniil P. Aksenov, Matthew Walker, Azur Azapagic, Jade Bookwalter, Ata Ullah, Himanshu Sant, Jill Shea, Bruce K. Gale
Формат: Artigo
Мова:Inglês
Опубліковано: Frontiers Media S.A. 2026-03-01
Серія:Frontiers in Oncology
Предмети:
brain
carmustine
direct delivery
osmotic pump
resection
temozolomide
Онлайн доступ:https://www.frontiersin.org/articles/10.3389/fonc.2026.1775053/full
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