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The thrombopoietin receptor: revisiting the master regulator of platelet production

Thrombopoietin (TPO) and its receptor, MPL, are the primary regulators of platelet production and critical for hematopoietic stem cell (HSC) maintenance. Since TPO was first cloned in 1994, the physiological and pathological roles of TPO and MPL have been well characterized, culminating in the first...

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Principais autores: Ian S. Hitchcock, Maximillian Hafer, Veena Sangkhae, Julie A. Tucker
Formato: Artigo
Idioma:Inglês
Publicado: Taylor & Francis Group 2021-08-01
Series:Platelets
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Acceso en liña:http://dx.doi.org/10.1080/09537104.2021.1925102
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