Blood multiomics reveal a dysregulated lipid mediator-mitochondrial network associated with the outcome of advanced cirrhosis

Abstract The mechanisms driving the progression from acutely decompensated (AD) cirrhosis to acute-on-chronic liver failure (ACLF), a high mortality condition, remain poorly understood. In this study, we integrate multiomics and clinical data from 766 AD patients to construct multiscale, multifactor...

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Autori principali:	Cristina López-Vicario, Ferran Aguilar, Fleur Chapus, Carlos de la Peña-Ramirez, François Fenaille, Florence Castelli, Marta Duran-Güell, Bryan J. Contreras, Berta Romero-Grimaldo, María Belén Sánchez-Rodríguez, Laura Valls-Roca, Glòria Garrabou, Sara Palomino-Echeverria, Estefania Huergo, Cristina Sanchez-Garrido, Wim Laleman, David Gómez-Cabrero, Alberto Queiroz Farias, Sebastián Marciano, Paolo Caraceni, Jonel Trebicka, Javier Fernández, Christophe Junot, Esther Titos, Richard Moreau, Vicente Arroyo, Pierre-Emmanuel Rautou, Joan Clària, On behalf of DECISION Consortium
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Nature Portfolio 2026-05-01
Serie:	Nature Communications
Accesso online:	https://doi.org/10.1038/s41467-026-73386-5
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