Impeding glial scarring hyperplasia and activating axon neogenesis via immunomodulatory microneedle patch for spinal cord repair

Abstract Immune dysregulation and scar tissue formation following traumatic spinal cord injury (SCI) result in the generation of a microenvironment that significantly inhibits nerve regeneration and functional recovery. Continuous drug delivery across the dura, with minimal damage, and modulation of...

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Detalhes bibliográficos

Principais autores:	Tao Zhou, Yajing Lin, Ying Wang, Lin Lin, Jingtong Li, Ning Tang, Yingji Mao, Pinghui Zhou
Formato:	Artigo
Idioma:	Inglês
Publicado em:	BMC 2026-05-01
Colecção:	Journal of Nanobiotechnology
Assuntos:	Microneedle patch Immune regulation Axon regeneration Zeolitic imidazolate framework-8 Chondroitinase ABC
Acesso em linha:	https://doi.org/10.1186/s12951-026-04568-y
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