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PI(4,5)P2 binding sites in the Ebola virus matrix protein VP40 modulate assembly and budding

Ebola virus (EBOV) causes severe hemorrhagic fever in humans and is lethal in a large percentage of those infected. The EBOV matrix protein viral protein 40 kDa (VP40) is a peripheral binding protein that forms a shell beneath the lipid bilayer in virions and virus-like particles (VLPs). VP40 is req...

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Autori principali: Kristen A. Johnson, Melissa R. Budicini, Nisha Bhattarai, Tej Sharma, Sarah Urata, Bernard S. Gerstman, Prem P. Chapagain, Sheng Li, Robert V. Stahelin
Natura: Artigo
Lingua:Inglês
Pubblicazione: Elsevier 2024-03-01
Serie:Journal of Lipid Research
Soggetti:
Ebola virus
lipid-protein interaction
phosphatidylserine
PI(4,5)P2
plasma membrane
protein oligomerization
Accesso online:http://www.sciencedirect.com/science/article/pii/S0022227524000178
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