Unravelling the mechanism of neurotensin recognition by neurotensin receptor 1
Abstract The conformational ensembles of G protein-coupled receptors (GPCRs) include inactive and active states. Spectroscopy techniques, including NMR, show that agonists, antagonists and other ligands shift the ensemble toward specific states depending on the pharmacological efficacy of the ligand...
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| Principais autores: | , , , , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
Nature Portfolio
2023-12-01
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| Series: | Nature Communications |
| Acceso en liña: | https://doi.org/10.1038/s41467-023-44010-7 |
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