The Role of Extracellular Proteases and Extracellular Matrix Remodeling in the Pre-Metastatic Niche

The premetastatic niche (PMN) represents a specialized microenvironment established in distant organs before the arrival of metastatic cells. This concept has fundamentally altered our understanding of cancer progression, shifting it from a random event-driven process to an orchestrated one. This re...

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Autores principales:	Gillian C. Okura, Alamelu G. Bharadwaj, David M. Waisman
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	MDPI AG 2025-12-01
Colección:	Biomolecules
Materias:	pre-metastatic niche matrix metalloproteases serine proteases plasminogen extracellular matrix remodeling cathepsins
Acceso en línea:	https://www.mdpi.com/2218-273X/15/12/1696
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