Characterizing the Hot Spots Involved in RON-MSPβ Complex Formation Using In Silico Alanine Scanning Mutagenesis and Molecular Dynamics Simulation

Purpose: Implication of protein-protein interactions (PPIs) in development of many diseases such as cancer makes them attractive for therapeutic intervention and rational drug design. RON (Recepteur d’Origine Nantais) tyrosine kinase receptor has gained considerable attention as promising target in...

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Prif Awduron:	Omid Zarei, Maryam Hamzeh-Mivehroud, Silvia Benvenuti, Fulya Ustun-Alkan, Siavoush Dastmalchi
Fformat:	Artigo
Iaith:	Inglês
Cyhoeddwyd:	Tabriz University of Medical Sciences 2017-04-01
Cyfres:	Advanced Pharmaceutical Bulletin
Pynciau:	Alanine screening Cancer Drug design Molecular dynamic simulation MSP RON
Mynediad Ar-lein:	http://journals.tbzmed.ac.ir/APB/Manuscript/APB-7-141.pdf
Tagiau:	Ychwanegu Tag Dim Tagiau, Byddwch y cyntaf i dagio'r cofnod hwn!