The interaction between virus-bound KLF4 and host-bound PARP1 directs the localization of wild-type adeno-associated virus type 2 (wtAAV2) to cellular sites of DNA damage

ABSTRACT Wild-type adeno-associated virus type 2 (wtAAV2) is a small, non-pathogenic DNA virus within the family Parvoviridae that is modified to engineer recombinant AAV vectors used in gene therapy. wtAAV2 genomes localize to nuclear domains enriched in DNA damage response (DDR) factors through me...

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Principais autores:	Rhiannon R. Abrahams, Clairine I. S. Larsen, Raymond Ha, Kinjal Majumder
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Microbiology 2026-05-01
Colecção:	Journal of Virology
Assuntos:	adeno-associated virus rAAV gene therapy DNA damage chromosome conformation capture
Acesso em linha:	https://journals.asm.org/doi/10.1128/jvi.00306-26
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